Noggin Protects Against Ischemic Brain Injury in Rodents

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Noggin protects against ischemic brain injury in rodents.

BACKGROUND AND PURPOSE Bone morphogenetic proteins and their receptors are expressed in adult brains, and their expression levels increase after cerebral ischemia. The brain also expresses an inhibitor of bone morphogenetic protein signaling, noggin, but the role of noggin in ischemic disease outcome has not been studied. METHODS We used transgenic mice overexpressing noggin to assess whether...

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ژورنال

عنوان ژورنال: Stroke

سال: 2010

ISSN: 0039-2499,1524-4628

DOI: 10.1161/strokeaha.109.565523